Open AccessHSPA4 Knockdown Retarded Progression and Development of Colorectal Cancer
Author(s) -
Mingliang Zhang,
Weijun Dai,
Zhanyu Li,
Liang Tang,
Jianhui Chen,
Chuangqi Chen
Publication year - 2021
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
ISSN - 1179-1322
DOI - 10.2147/cmar.s310729
Subject(s) - gene knockdown , cancer research , carcinogenesis , gene silencing , cyclin dependent kinase 6 , cell growth , cell cycle , biology , protein kinase b , small hairpin rna , apoptosis , tumor progression , pi3k/akt/mtor pathway , colorectal cancer , cell cycle checkpoint , cyclin d1 , cancer , gene , biochemistry , genetics
Colorectal cancer (CRC) is a common malignancy associated with high morbidity and mortality. Heat shock 70 kDa protein 4 (HSPA4) has been shown to exert regulatory roles during tumor progression in different cancer types. Here, we investigated the expression and cellular functions of HSPA4 in CRC.