Open AccessCD44+ Circulating Tumor Endothelial Cells Indicate Poor Prognosis in Pancreatic Ductal Adenocarcinoma After Radical Surgery: A Pilot Study
Author(s) -
Xing Cheng,
Yatong Li,
Cheng Ding,
Shunda Wang,
Hanyu Zhang,
Lixin Chen,
Pengyu Li
Publication year - 2021
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s309115
Subject(s) - medicine , univariate analysis , immunostaining , cd44 , adenocarcinoma , lymph , venous blood , pathology , radical surgery , gastroenterology , oncology , cancer , immunohistochemistry , multivariate analysis , cell , genetics , biology
Circulating tumor endothelial cells (CTECs) are cells that originate from tumor endothelial cells (TECs) of blood vessels and are shed into peripheral blood. Some studies have shown that CTECs are associated with tumor angiogenesis, growth and indicate prognosis in patients with malignant solid tumor. However, the role of CTECs especially the phenotype of CTECs in pancreatic adenocarcinoma (PDAC) is still not clear. We investigated the relationship between CTECs and patients' prognosis.