Open AccessThe Biological Function of TUSC7/miR-1224-3p Axis in Triple-Negative Breast Cancer
Author(s) -
Zheng Bao,
Zhiqiang He,
Juan Zhang,
Jingjing Ma,
Hongwei Zhang,
Wei Zhu,
Zhimin Shao,
Xiaojian Ni
Publication year - 2021
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s305865
Subject(s) - cancer research , triple negative breast cancer , breast cancer , pi3k/akt/mtor pathway , protein kinase b , gene knockdown , ectopic expression , pten , cancer , biology , cell growth , mapk/erk pathway , kinase , medicine , signal transduction , microbiology and biotechnology , cell culture , genetics
Triple-negative breast cancers (TNBC), comprising about 20% of breast cancers, have a poor prognosis. Currently, there is no effective target therapy for TNBC. LncRNA TUSC7 has been identified as a tumor suppressor in osteosarcoma and colorectal cancer. In this study, we investigated the clinical significance and the biological function of TUSC7 in breast cancer.