Open AccessObesity Promotes Tumor Immune Evasion in Ovarian Cancer Through Increased Production of Myeloid-Derived Suppressor Cells via IL-6
Author(s) -
Qiannan Yang,
Bojun Yu,
Jiuhong Kang,
Ang Li,
Jing Sun
Publication year - 2021
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s303707
Subject(s) - ovarian cancer , medicine , tumor microenvironment , immune system , adipose tissue , cancer , endocrinology , myeloid derived suppressor cell , bone marrow , ovarian tumor , cancer research , immunology , suppressor
Obesity is defined as a chronic, low-grade inflammatory disease that can cause obesity-associated disorders, such as cancer. Obesity has traditionally been thought to be a risk factor for ovarian cancer. Few reports have focused on the specific pathogenesis of obesity-related ovarian cancer. When considering the correlation between obesity and the relative risk of death from ovarian cancer, we investigated whether obesity promotes tumor immune escape in ovarian cancer.