Open AccessOral Tongue Cancer in a Patient with Fanconi Anemia: A Case Report and Literature Review
Author(s) -
Siyao Deng,
Wenjing Ye,
Shichuan Zhang,
Guiquan Zhu,
Peng Zhang,
Yupeng Song,
Fang-Lei Duan,
Jinyi Lang,
Shun Lü
Publication year - 2021
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s301582
Subject(s) - fanconi anemia , tongue , medicine , cancer , anemia , dermatology , pediatrics , pathology , genetics , biology , dna repair , dna
Fanconi anemia (FA) is a rare genetic disorder characterized by congenital anomalies, progressive bone marrow failure and high susceptibility to solid tumors, especially head and neck squamous cell carcinoma (HNSCC). Management of FA patients with head and neck cancer is a challenge due to increased risk of surgery, poor tolerance of chemotherapy, and severe myelotoxicity of radiotherapy.