Open AccessUSP8 is a Novel Therapeutic Target in Melanoma Through Regulating Receptor Tyrosine Kinase Levels
Author(s) -
Baoxue Duan,
Changying Wang,
Zeng Liu,
Xiaoyu Yang
Publication year - 2021
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s300195
Subject(s) - cancer research , melanoma , receptor tyrosine kinase , deubiquitinating enzyme , gene knockdown , biology , cell growth , downregulation and upregulation , signal transduction , apoptosis , ubiquitin , microbiology and biotechnology , gene , biochemistry , genetics
The hyperactivation of receptor tyrosine kinase (RTK)-mediated pathways plays an important role in melanoma progression and resistance to therapy. The ubiquitin-specific protease 8 (USP8) is a deubiquitinating enzyme and its inhibition induces degradation of RTKs. This work explored the expression and role of USP8 in melanoma.