Open AccessTGF-β-MTA1-SMAD7-SMAD3-SOX4-EZH2 Signaling Axis Promotes Viability, Migration, Invasion and EMT of Hepatocellular Carcinoma Cells
Author(s) -
Kangjun Zhang,
Taishi Fang,
Yajie Shao,
Yanhui Wu
Publication year - 2021
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s297765
Subject(s) - vimentin , cancer research , ezh2 , gene silencing , transforming growth factor , viability assay , epithelial–mesenchymal transition , biology , small interfering rna , cell culture , transfection , chemistry , metastasis , microbiology and biotechnology , immunology , gene expression , cancer , immunohistochemistry , biochemistry , genetics , gene
Enhancer of zeste homolog 2 (EZH2) is implicated in hepatocellular carcinoma (HCC), but whether transforming growth factor-β (TGF-β)-metastasis associated 1 (MTA1)-SMAD7-SMAD3-SRY-Box Transcription Factor 4 (SOX4)-EZH2 signaling axis, in which EZH2 participates, is also involved in HCC remained unknown.