Open AccessHER2 Overexpression and Mismatch Repair Deficiency are Correlated with Malignancy in Colorectal Cancer
Author(s) -
Luo Hai,
Lingzhi Cui,
Kongchao Shen,
Ruiqi Li,
Zeming Wang,
Zhixun Xie
Publication year - 2021
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
ISSN - 1179-1322
DOI - 10.2147/cmar.s297596
Subject(s) - medicine , pms2 , colorectal cancer , oncology , mlh1 , immunohistochemistry , clinical significance , malignancy , carcinoembryonic antigen , microsatellite instability , msh6 , stage (stratigraphy) , dna mismatch repair , cancer , pathology , biology , gene , paleontology , allele , biochemistry , microsatellite
This study was designed to investigate the correlation between the expression of human epidermal growth factor receptor 2 (HER2), mismatch repair (MMR), and clinicopathological parameters and serum tumor markers in a total of 522 resection samples materials from colorectal cancer (CRC) patients. These data were also used to determine the links between HER2 and MMR expression and prognosis.