Open AccessMolecular Heterogeneity of Xp11.2 Translocation Renal Cell Carcinoma: The Correlation Between Split Signal Pattern in FISH and Prognosis
Author(s) -
Yiqi Zhu,
Xiaohong Pu,
Xiang Da Dong,
Changwei Ji,
Hongqian Guo,
Dongmei Li,
Xiaozhi Zhao,
Weidong Gan
Publication year - 2021
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s297457
Subject(s) - chromosomal translocation , renal cell carcinoma , tfe3 , nephrectomy , fluorescence in situ hybridization , biology , proportional hazards model , pathology , medicine , kidney , gene , genetics , gene expression , chromosome , promoter
Xp11.2 translocation renal cell carcinoma (Xp11.2 tRCC) is a distinct subtype of renal cell carcinoma (RCC) characterized by chromosomal translocations involving TFE3 gene. TFE3 break-apart fluorescence in situ hybridization (FISH) assay is an effective tool to diagnose Xp11.2 tRCC. The aim of this study is to evaluate the correlation between split signal pattern in FISH and the clinicopathological characteristics of Xp11.2 tRCC.