Open AccessClinical Significance of Monitoring Circulating Free DNA and Plasma Heat Shock Protein 90alpha in Patients with Esophageal Squamous Cell Carcinoma
Author(s) -
Qiang Zhao,
Congxiu Miao,
Qingpu Lu,
Weipeng Wu,
Yonghong He,
Shouxin Wu,
Huimin Liu,
Changhong Lian
Publication year - 2021
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
ISSN - 1179-1322
DOI - 10.2147/cmar.s295927
Subject(s) - medicine , biomarker , oncology , esophageal cancer , esophageal squamous cell carcinoma , heat shock protein , clinical significance , cancer , carcinoma , gastroenterology , biology , biochemistry , gene
Esophageal squamous cell carcinoma (ESCC) is the predominant histological type of esophageal cancer in China and has an extremely poor prognosis. Circulating free DNA (cfDNA) and plasma heat shock protein 90alpha (Hsp90a) are two novel noninvasive biomarkers for diagnosis and prognostic prediction of several types of cancer. However, to the best of our knowledge, the roles of the two biomarkers in ESCC are still unknown.