Open AccessLow-Coverage Sequencing of Urine Sediment DNA for Detection of Copy Number Aberrations in Bladder Cancer
Author(s) -
Yunxi Cai,
Xu Yang,
Shiu-Shiung Lin,
Yuhong Xu,
Shan-wen Zhu,
Daiming Fan,
Min Zhao,
Yuanbin Zhang,
Xiaobo Yang,
Xin Li
Publication year - 2021
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s295675
Subject(s) - bladder cancer , cdkn2a , urine , cancer , gene duplication , dna sequencing , medicine , whole genome sequencing , dna , biology , genome , urology , gene , genetics
Chromosomal copy number aberrations (CNAs) are a hallmark of bladder cancer and a useful target for diagnostic explorations. Here we constructed a low-coverage whole-genome sequencing method for the detection of CNAs in urine sediment DNA from patients with bladder cancer.