Open AccessCircPRDM2 Contributes to Doxorubicin Resistance of Osteosarcoma by Elevating EZH2 via Sponging miR-760
Author(s) -
Jianjun Yuan,
Yan Liu,
Quan Zhang,
Zhishuai Ren,
Guang Li,
Rong Tian
Publication year - 2021
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s295147
Subject(s) - flow cytometry , gene knockdown , cancer research , cell growth , osteosarcoma , ezh2 , gene silencing , apoptosis , microrna , microbiology and biotechnology , chemistry , cell , biology , methylation , gene , biochemistry
Circular RNAs (circRNAs) are implicated in the chemoresistance of human cancers. However, the functions of circRNA PR/SET domain 2 (circPRDM2) in the resistance of osteosarcoma (OS) to doxorubicin (DXR) are unknown.