Open AccessMicroRNA-32 and MicroRNA-548a Promote the Drug Sensitivity of Non-Small Cell Lung Cancer Cells to Cisplatin by Targeting ROBO1 and Inhibiting the Activation of Wnt/β-Catenin Axis
Author(s) -
Jian Zheng,
Xiaoxi Li,
Cunwei Cai,
Chengyu Hong,
Bin Zhang
Publication year - 2021
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s295003
Subject(s) - wnt signaling pathway , cisplatin , microrna , cancer research , gene knockdown , lung cancer , carcinogenesis , catenin , cell growth , biology , cancer , chemistry , cell culture , medicine , oncology , signal transduction , microbiology and biotechnology , chemotherapy , gene , biochemistry , genetics
The roles of microRNA (miR)-32 and miR-548a in non-small cell lung cancer (NSCLC) have been studied. But their influences on NSCLC cells to cisplatin (DDP) resistance remain elusive. This study estimated the mechanisms of miR-32 and miR-548a in NSCLC cells to DDP.