Open AccessPretreatment Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio as Prognostic Factors and Reference Markers of Treatment Options for Locally Advanced Squamous Cell Carcinoma Located in the Middle and Upper Esophagus
Author(s) -
Chen Wang,
Jiaqi Tong,
Mengqiu Tang,
Yonglai Lu,
Gaofeng Liang,
Zhanchun Zhang,
Chen Tian
Publication year - 2021
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s294344
Subject(s) - medicine , neutrophil to lymphocyte ratio , proportional hazards model , gastroenterology , receiver operating characteristic , univariate analysis , stage (stratigraphy) , oncology , multivariate analysis , population , lymphocyte , paleontology , environmental health , biology
Various inflammatory biomarkers, such as the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR), have been well authenticated to predict clinical outcomes in numerous types of cancer. The optimal treatment for patients with locally advanced esophageal squamous cell carcinoma (ESCC) located in the middle or upper region is still inconclusive. The aim of the study was to examine pretreatment NLR and PLR to select from radical surgery or definitive chemoradiotherapy (dCRT) for these patients. The linkage between pretreatment NLR/PLR and prognosis was also analyzed.