Open AccessNrf2/HO-1 Axis Regulates the Angiogenesis of Gastric Cancer via Targeting VEGF
Author(s) -
Yunning Huang,
Yuanyuan Yang,
Yang Xu,
Qian Ma,
Fengying Guo,
Yuan Zhao,
Yuejia Tao,
Mengqi Li,
Jiaxin Guo
Publication year - 2021
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
ISSN - 1179-1322
DOI - 10.2147/cmar.s292461
Subject(s) - angiogenesis , blot , immunohistochemistry , immunofluorescence , vascular endothelial growth factor , microvessel , chemistry , cancer , immunocytochemistry , microbiology and biotechnology , pathology , hypoxia inducible factors , heme oxygenase , cancer research , biology , medicine , immunology , antibody , vegf receptors , gene , biochemistry , heme , enzyme
Gastric cancer (GC) is one of the most fatal digestive tumors worldwide. Abnormal activation or accumulation of the nuclear factor-erythroid 2-related factor 2/heme oxygenase 1 (Nrf2/HO-1) axis is a malignant event in numerous solid tumors. However, its involvement in angiogenesis of GC remains unknown. This study investigated the role of the Nrf2/HO-1 axis in angiogenesis of GC.