Open AccessCircular RNA CircEPB41L2 Functions as Tumor Suppressor in Hepatocellular Carcinoma Through Sponging miR-590-5p
Author(s) -
Feng Chen,
Lei He,
Liman Qiu,
Yang Zhou,
Zhenli Li,
Geng Chen,
Fuli Xin,
Xiaoli Dong,
Haipo Xu,
Gaoxiong Wang,
Jingfeng Liu,
Zhixiong Cai
Publication year - 2021
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s291682
Subject(s) - gene knockdown , hepatocellular carcinoma , cancer research , microrna , western blot , metastasis , reporter gene , cell growth , cell culture , real time polymerase chain reaction , biology , luciferase , gentamicin protection assay , gene expression , gene , cancer , transfection , biochemistry , genetics
Circular RNAs (circRNAs) could interact with miRNAs to regulate gene expression, participating in hepatocellular carcinoma (HCC) initiation and development. This work aimed to determine the potential function and molecular mechanism of circEPB41L2 (hsa_circ_0077837) during HCC progression.