Open AccessComprehensive Molecular Characterization of Chinese Patients with Glioma by Extensive Next-Generation Sequencing Panel Analysis
Author(s) -
Chun Zeng,
Jing Wang,
Mingwei Li,
Huina Wang,
Li Feng,
Shanbo Cao,
Changyu Lu
Publication year - 2021
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s291681
Subject(s) - cdkn2a , atrx , pdgfra , glioma , idh1 , pten , hras , biology , genetics , population , gene , grading (engineering) , neuroblastoma ras viral oncogene homolog , exon , kras , cancer research , oncology , mutation , medicine , apoptosis , ecology , gist , environmental health , stromal cell , pi3k/akt/mtor pathway
Tremendous efforts have been made to explore biomarkers for classifying and grading glioma. However, the majority of the current understanding is based on public databases that might not accurately reflect the Asian population. Here, we investigated the genetic landscape of Chinese glioma patients using a validated multigene next-generation sequencing (NGS) panel to provide a strong rationale for the future classification and prognosis of glioma in this population.