Open AccessWNT5a in Colorectal Cancer: Research Progress and Challenges
Author(s) -
Guan Sun,
Liangliang Wu,
Guoqiang Sun,
Xianzhe Shi,
Hongxin Cao,
Weiwei Tang
Publication year - 2021
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s289819
Subject(s) - colorectal cancer , autocrine signalling , wnt signaling pathway , paracrine signalling , wnt5a , medicine , cancer , cancer research , adjuvant , oncology , mouse model of colorectal and intestinal cancer , mechanism (biology) , surgical oncology , disease , bioinformatics , signal transduction , biology , receptor , biochemistry , philosophy , epistemology
Despite the clinical development of new adjuvant and neoadjuvant chemotherapy drugs, colorectal cancer is still one of the leading causes of cancer-related death in human beings. WNT5a, an autocrine and paracrine β-catenin independent ligand, has been shown to induce tumor inhibition and carcinogenic signals, depending on the type of cancer. In patients with colorectal cancer, WNT5a triggers a variety of downstream signaling pathways, which mainly affect the migration and invasion of tumor cells. This article reviews the mechanism and therapeutic potential of WNT5a in colorectal cancer. In short, an in-depth understanding of the role of WNT5a in colorectal cancer is very helpful to better deal with this disease.