Open AccessTRIB3 Promotes Lung Adenocarcinoma Progression via an Enhanced Warburg Effect
Author(s) -
Yanfeng Xing,
Peng Luo,
Rui Hu,
Duanduan Wang,
Gang Zhou,
Jie Jiang
Publication year - 2020
Publication title -
cancer management and research
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s287956
Subject(s) - warburg effect , cancer research , lung , adenocarcinoma , chemistry , lung cancer , microbiology and biotechnology , medicine , biology , glycolysis , cancer , metabolism
The pseudokinase Tribbles 3 (TRIB3) is involved in many cellular processes and various cancers. In recent years, the importance of metabolic transformation in the maintenance of malignant tumors has become increasingly prominent. Abnormal metabolism of cancer cells is considered a hallmark of cancer. However, the exact role and molecular mechanism of TRIB3 in lung adenocarcinoma (LUAD) cell reprogramming is largely unknown.