Open AccessClinicopathologic Factors Associated with Mismatch Repair Status Among Filipino Patients with Young-Onset Colorectal Cancer
Author(s) -
Dennis Lee Sacdalan,
Reynaldo L. Garcia,
Michele H. Diwa,
Danielle Benedict Sacdalan
Publication year - 2021
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s286618
Subject(s) - msh6 , microsatellite instability , pms2 , msh2 , mlh1 , medicine , dna mismatch repair , colorectal cancer , cancer , lynch syndrome , rectum , oncology , family history , population , ascending colon , gastroenterology , pathology , biology , microsatellite , allele , biochemistry , environmental health , gene
Young-onset colorectal cancer is recognized as a distinct disease that may be sporadic or hereditary in nature. Microsatellite instability testing is recommended as a routine procedure in evaluating colorectal cancer specimens, especially in young-onset disease, because of implications in management. Immunohistochemistry of mismatch repair proteins serves as an inexpensive alternative to microsatellite instability testing with the added advantage of monitoring protein expression levels that may suggest underlying genetic or epigenetic alterations. This descriptive study aimed to determine the frequencies of proficient and deficient mismatch repair status among Filipino young-onset colorectal cancer patients, and to investigate their clinicopathologic profile.