Open Access<p>Upregulated Histone Deacetylase 6 Associates with Malignant Progression of Melanoma and Predicts the Prognosis of Patients</p>
Author(s) -
Zhicheng Hu,
Yanchao Rong,
Shuting Li,
Shanqiang Qu,
Shaobin Huang
Publication year - 2020
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
ISSN - 1179-1322
DOI - 10.2147/cmar.s284199
Subject(s) - melanoma , hdac6 , medicine , biomarker , oncology , histone deacetylase , cancer research , metastasis , cancer , histone , biology , gene , biochemistry
Melanoma is the most malignant tumor among skin tumors, and its morbidity and mortality are increasing year by year. Although melanoma biology has been increasingly studied, no prognostic biomarkers have yet been incorporated into clinical protocols. Histone deacetylase 6 ( HDAC6 ) has been shown to act as a prognostic biomarker in several cancers. Here, we aimed to investigate the predictive value of HDAC6 for the prognosis of cutaneous melanoma patients.