Open AccessApolipoprotein E2 Promotes the Migration and Invasion of Pancreatic Cancer Cells via Activation of the ERK1/2 Signaling Pathway
Author(s) -
Hui Wang,
Shaoxia Du,
Jin Cai,
Juan Wang,
Xiaohong Shen
Publication year - 2020
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s284115
Subject(s) - pancreatic cancer , metastasis , cancer research , cell migration , matrigel , epithelial–mesenchymal transition , cancer , signal transduction , cancer cell , chemistry , cell , biology , medicine , microbiology and biotechnology , angiogenesis , biochemistry
Apolipoprotein E2 (ApoE2) is reported to be essential for cell metastasis and proliferation and has been considered a potential diagnostic marker in many cancers. However, the function of ApoE2 in the metastasis of pancreatic cancer, as well as the underlying mechanism, remain unclear.