Open AccessExosomal miR-499a-5p Inhibits Endometrial Cancer Growth and Metastasis via Targeting VAV3
Author(s) -
Jing Liang,
Hui Xu,
Yifeng Du,
Zang Rukun,
Junjun Mou
Publication year - 2020
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s283747
Subject(s) - endometrial cancer , cancer research , metastasis , microvesicles , angiogenesis , microrna , cell growth , exosome , cancer , cancer cell , mesenchymal stem cell , electroporation , biology , chemistry , medicine , pathology , gene , biochemistry , genetics
The current therapeutic strategies for endometrial cancer are limited and unsatisfactory. Accumulating evidence suggest that microRNAs (miRNAs) participate in tumor growth and metastasis. Mesenchymal stem cells (MSCs) derived exosomes (Exos) are considered as better miRNA delivery vehicles. Here, we investigated the therapeutic effect of exosomal miR-499a-5p (miR-499) in human endometrial cancer metastasis.