Open AccessInhibition of Bone Morphogenetic Protein 2 Suppresses the Stemness Maintenance of Cancer Stem Cells in Hepatocellular Carcinoma via the MAPK/ERK Pathway
Author(s) -
Juncheng Guo,
Min Guo,
Jinfang Zheng
Publication year - 2021
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s281969
Subject(s) - cancer research , mapk/erk pathway , bone morphogenetic protein 2 , cancer stem cell , gene knockdown , bone morphogenetic protein , downregulation and upregulation , epithelial–mesenchymal transition , gene silencing , cancer , chemistry , stem cell , metastasis , biology , microbiology and biotechnology , medicine , signal transduction , cell culture , in vitro , biochemistry , genetics , gene
Hepatocellular carcinoma (HCC) remains a life-threatening malignant tumor. Cancer stem cells (CSCs) harbor tumor-initiating capacity and can be used as a therapeutic target for human malignancies. Bone morphogenetic proteins (BMPs) play a regulatory role in CSCs. This study investigated the role and mechanism of BMP2 in CSCs in HCC.