Open Access<p>Azoxystrobin Reduces Oral Carcinogenesis by Suppressing Mitochondrial Complex III Activity and Inducing Apoptosis</p>
Author(s) -
Hui Chen,
Lingyu Li,
Yao Lu,
Yi Shen,
Min Zhang,
Li Ge,
Min Wang,
Jing Yang,
Zhenchuan Tian,
Xiaofei Tang
Publication year - 2020
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s280285
Subject(s) - apoptosis , viability assay , carcinogenesis , cell cycle , flow cytometry , reactive oxygen species , biology , mitochondrial ros , cell , cancer research , microbiology and biotechnology , cancer , chemistry , biochemistry , genetics
The five-year survival rate of patients with oral cancer is approximately 50%; thus, alternative drugs with higher efficacy are urgently required. Azoxystrobin (AZOX), a natural, novel methoxyacrylate fungicide isolated from mushrooms, has a broad-spectrum, with highly efficient bactericidal effect. However, studies on AZOX have focused on antifungal effects. Here, we explore the potential cancer-preventive effects of AZOX and the underlying mechanisms.