Open AccessCyclin F Downregulation Affects Epithelial-Mesenchymal Transition Increasing Proliferation and Migration of the A-375 Melanoma Cell Line
Author(s) -
Adrian Krajewski,
Maciej Gagat,
Klaudia Mikołajczyk,
Magdalena Izdebska,
Agnieszka Żuryń,
Alina Grzanka
Publication year - 2020
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s279169
Subject(s) - microbiology and biotechnology , cell cycle , cyclin a , cyclin b1 , cyclin b , cyclin d , biology , cyclin a2 , cyclin e , cyclin , cyclin dependent kinase 1 , epithelial–mesenchymal transition , cyclin d1 , chemistry , downregulation and upregulation , cell , biochemistry , gene
Cyclins are well-known cell cycle regulators. The activation of cyclin-dependent kinases by cyclins allows orchestration of the complicated cell cycle machinery and drives the cell from the G1 phase to the end of the mitotic phase. In recent years, it has become evident that cyclins are involved in processes beyond the cell cycle. Cyclin F does not activate CDKs but forms part of the Skp1-Cul1-F-box (SCF) complex where it is responsible for protein target recognition and subsequent degradation in a proteasome-dependent manner.