Open Access<p>Mannose Impairs Lung Adenocarcinoma Growth and Enhances the Sensitivity of A549 Cells to Carboplatin</p>
Author(s) -
Jun Sha,
Dandan Cao,
Rui Cui,
Xia Lu,
Xin Hua,
Yuan Lu,
Shuhua Han
Publication year - 2020
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s278673
Subject(s) - mannose , carboplatin , a549 cell , tunel assay , mannose receptor , chemistry , apoptosis , cancer research , in vitro , biology , biochemistry , medicine , chemotherapy , cisplatin , macrophage
Mannose, a major monosaccharide component of N-glycans, involves in the glycometabolism of human body. Recently, mannose has been shown to suppress tumor growth through enhancing chemosensitivity and reducing the activity of mannose phosphate isomerase (MPI). However, it is largely unknown whether mannose exerts effects on non-small cell lung cancer (NSCLC).