Open AccessAnti-Tumor Effect of Celastrol on Hepatocellular Carcinoma by the circ_SLIT3/miR-223-3p/CXCR4 Axis
Author(s) -
Hailong Si,
Huiling Wang,
Haijuan Xiao,
Yu Fang,
Zhaoli Wu
Publication year - 2021
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
ISSN - 1179-1322
DOI - 10.2147/cmar.s278023
Subject(s) - celastrol , cancer research , apoptosis , in vivo , cell growth , chemistry , flow cytometry , gene knockdown , cxcr4 , microbiology and biotechnology , biology , receptor , chemokine , biochemistry
Celastrol is a potential anti-tumor agent in hepatocellular carcinoma (HCC). Identifying the molecular determinants of the anti-HCC effect of celastrol is still challenging. In this study, we undertook to associate circular RNAs (circRNAs) with the anti-HCC molecular determinants of celastrol.