Open AccessSLAMF1 Promotes Methotrexate Resistance via Activating Autophagy in Choriocarcinoma Cells
Author(s) -
Dazun Shi,
Yu Zhang,
Yan Tian
Publication year - 2020
Publication title -
cancer management and research
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s278012
Subject(s) - autophagy , viability assay , cell culture , choriocarcinoma , cancer research , intracellular , cell , chemistry , microbiology and biotechnology , apoptosis , biology , biochemistry , genetics
The acquisition of chemoresistance to methotrexate (MTX) still remains one of the major challenges for choriocarcinoma treatment. Herein, we aimed to evaluate the potential role of Signaling Lymphocytic Activation Molecule Family Member 1 (SLAMF1) as a possible regulator of chemoresistance to MTX in choriocarcinoma.