Open AccessLncRNA UCA1 Enhances Cisplatin Resistance by Regulating CYP1B1-mediated Apoptosis via miR-513a-3p in Human Gastric Cancer
Author(s) -
Cheng Huang,
Gaowa Sharen,
Zhaoyang Wang,
Jing Zhou
Publication year - 2021
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s277399
Subject(s) - gene knockdown , cisplatin , apoptosis , cancer research , flow cytometry , cyp1b1 , biology , cancer cell , cancer , cell , chemistry , microbiology and biotechnology , chemotherapy , biochemistry , genetics , cytochrome p450 , metabolism
Chemoresistance contributes to treatment failure of gastric cancer (GC) patients but the molecular mechanism of chemoresistance in GC is still unclear. Long-chain noncoding RNA (lncRNA) urothelial cancer associated 1 ( UCA1 ) is associated with resistance to chemotherapy drugs.