Open Access<p>Adipose-Derived Stem Cells Promote Proliferation and Invasion in Cervical Cancer by Targeting the HGF/c-MET Pathway</p>
Author(s) -
Yongning Zhai,
Wangfei Wu,
Xiaowei Xi,
Rongbin Yu
Publication year - 2020
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s277130
Subject(s) - hepatocyte growth factor , paracrine signalling , hela , cancer research , stem cell , cell culture , chemistry , medicine , biology , microbiology and biotechnology , receptor , genetics
Cervical cancer is a serious female malignancy affecting women's health worldwide. The HGF/c-MET signaling pathway is activated in cervical cancer. Adipose-derived stem cells (ADSCs) with multipotential differentiation can carry out paracrine secretion of hepatocyte growth factor (HGF). Here, we investigated the effect and underlying mechanism of ADSCs on the promotion and invasion of cervical cancer in vitro and in vivo.