Open AccessA Novel, Personalized Drug-Screening System for Platinum-Resistant Ovarian Cancer Patients: A Preliminary Clinical Report
Author(s) -
Yunke Huang,
Jing Xu,
Ké Li,
Jing Wang,
Yilin Dai,
Yu Kang
Publication year - 2021
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
ISSN - 1179-1322
DOI - 10.2147/cmar.s276799
Subject(s) - medicine , drug , oncology , ovarian cancer , personalized medicine , clinical trial , chemotherapy , cancer , disease , carboplatin , pharmacology , bioinformatics , cisplatin , biology
With this study, we intended to construct a personalized drug-screening system for platinum-resistant ovarian cancer patients by consulting a patient's medical history, data derived from gene mutation detection, and drug screening results derived from mini-PDX (patient-derived xenograft) models. We also aimed to evaluate the efficacy and safety of our system.