Open Access<p>Analyses of Potential Driver and Passenger Bacteria in Human Colorectal Cancer</p>
Author(s) -
Yijia Wang,
Chunze Zhang,
Shaobin Hou,
Xiaojing Wu,
Jun Li,
Xuehua Wan
Publication year - 2020
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s275316
Subject(s) - colorectal cancer , bacteria , medicine , cancer , cancer research , oncology , biology , genetics
Besides genetic and epigenetic alterations that lead to carcinogenesis and development of colorectal cancer (CRC), intestinal microbiomes are recently recognized to play a critical role in CRC progression. The abundant species associated with human CRC have been proposed for their roles in promoting tumorigenesis. However, a recent "driver-passenger" model suggests that these CRC-associated species with high relative abundances may be passenger bacteria that take advantage of the tumor environment instead of initiating CRC, whereas the driver species that initiate CRC have been replaced by passenger bacteria due to the alteration of the intestinal niche.