Open Access<p>PD-L1 Expression is Highly Associated with Tumor-Associated Macrophage Infiltration in Nasopharyngeal Carcinoma</p>
Author(s) -
Rui Deng,
Juan Lü,
Xiong Liu,
Xiaohong Peng,
Jie Wang,
Xiangping Li
Publication year - 2020
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s274913
Subject(s) - cd163 , cd68 , tumor microenvironment , nasopharyngeal carcinoma , tumor associated macrophage , pd l1 , immunohistochemistry , cytotoxic t cell , cancer research , tumor infiltrating lymphocytes , immune system , macrophage , m2 macrophage , medicine , biology , chemistry , immunology , immunotherapy , radiation therapy , in vitro , biochemistry
Tumour-associated macrophages (TAMs) are the most abundant immune cells in the tumor microenvironment and provide a barrier against the cytotoxic effector functions of T cells and natural killer (NK) cells. Recently, TAMs have become increasingly recognised as an attractive target in combination therapy with PD-1/PD-L1 immuno-checkpoint blockades (ICBs). However, the relationship between PD-L1 expression and TAMs remains unknown in nasopharyngeal carcinoma (NPC).