Open Access<p>Phosphorylated MAPK14 Promotes the Proliferation and Migration of Bladder Cancer Cells by Maintaining RUNX2 Protein Abundance</p>
Author(s) -
Junlong Liu,
Xiuyue Yu,
Bitian Liu,
Hongyuan Yu,
Zhenhua Li
Publication year - 2020
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s274058
Subject(s) - mapk14 , cancer research , bladder cancer , biology , cancer , kinase , protein kinase a , microbiology and biotechnology , cyclin dependent kinase 2 , genetics
Mitogen-activated protein kinase 14 ( MAPK14 ) acts as an integration point for multiple biochemical signal pathways. High expressions of MAPK14 have been found in a variety of tumors. Runt‑related transcription factor 2 ( RUNX2 ) is related to many tumors, especially in tumor invasion and metastasis. However, the mechanism of these two genes in bladder cancer remains unclear.