Open Access<p>Melanoma-Derived Exosomes Endow Fibroblasts with an Invasive Potential via miR-21 Target Signaling Pathway</p>
Author(s) -
Chen-meiyi Wang,
Yi-Ting Wang,
Xiulin Chang,
Xiaoyun Ba,
Na Hu,
Qing Liu,
Liaoqiong Fang,
Zhibiao Wang
Publication year - 2020
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s273718
Subject(s) - microvesicles , exosome , mmp2 , cancer research , fibroblast , tumor microenvironment , mmp9 , stromal cell , metastasis , tumor progression , biology , chemistry , microbiology and biotechnology , microrna , cell culture , downregulation and upregulation , cancer , tumor cells , biochemistry , genetics , gene
Tumor-derived exosomes are messengers that participate in tumor progression. Fibroblasts are associated with the metastasis of cancer depending on their cellular plasticity. We hypothesize that tumor-derived exosomes endow the fibroblasts in tumor microenvironment with invasive phenotype to the benefit of tumor metastasis.