Open Access<p>Evaluating the Performance of p16<sup>INK4a</sup> Immunocytochemistry in Cervical Cancer Screening</p>
Author(s) -
Fangbin Song,
Hui Du,
Xiao Ai-min,
Chun Wang,
Xia Huang,
Peisha Yan,
Zhihong Liu,
Xinfeng Qu,
Jerome L. Belinson,
Ruifang Wu
Publication year - 2020
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s273079
Subject(s) - medicine , cytology , cervical intraepithelial neoplasia , cervical cancer , liquid based cytology , cervical screening , biopsy , cervical cancer screening , colposcopy , gynecology , cancer , oncology , pathology , gastroenterology
When used for cervical cancer primary screening, liquid-based cytology (LBC) has a high specificity but a low sensitivity. For histological diagnosis of high-grade lesions, p16 INK4a immunostaining has proven to be useful. Therefore, our objective was to evaluate the use of p16 INK4a immuno-cytology as a primary screen and a secondary screen after primary high-risk human papillomavirus (hrHPV) screening or LBC screening.