Open Access<p>CircNFIX Acts as a miR-212-3p Sponge to Enhance the Malignant Progression of Non-Small Cell Lung Cancer by Up-Regulating ADAM10</p>
Author(s) -
Jun Lü,
Ying Zhu,
Youfa Qin,
Yikai Chen
Publication year - 2020
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s272309
Subject(s) - gene knockdown , viability assay , cancer research , gene silencing , carcinogenesis , adam10 , cell growth , lung cancer , biology , cell , cancer , chemistry , microbiology and biotechnology , medicine , apoptosis , pathology , metalloproteinase , disintegrin , matrix metalloproteinase , gene , biochemistry , genetics
Non-small cell lung cancer (NSCLC) remains the most commonly diagnosed malignancy and the leading cause of cancer death worldwide. Circular RNAs (circRNAs) have been demonstrated to play critical roles in human carcinogenesis, including NSCLC. However, it is still unclear whether circRNA nuclear factor I X (circNFIX) is implicated in the molecular pathogenesis of NSCLC.