Open Access<p>Upregulated Long Non-Coding RNA LL22NC03-N64E9.1 Promotes the Proliferation and Migration of Human Breast Cancer Cells by Silencing Kruppel-Like Factor 2 Expression</p>
Author(s) -
Weibin Lian,
Xiaohua Jiang,
Liangqiang Li,
Qinglan Wang,
Chengye Hong,
Peidong Yang,
Debo Chen
Publication year - 2020
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s268725
Subject(s) - gene silencing , cell growth , carcinogenesis , cancer research , biology , ezh2 , long non coding rna , downregulation and upregulation , gene knockdown , cancer , histone , cell culture , gene , genetics
Recently, the significant regulatory effects of lncRNAs on the oncogenesis and growth of tumor have been demonstrated by an increasing number of research projects. A previous study showed that LL22NC03-N64E9.1 could promote the development of colorectal cancer, especially via enhanced cell proliferation. Similarly, this lncRNA should have comparable functions in breast cancer (BC), which requires in-depth investigation. Therefore, this study was designed to explore the correlation of LL22NC03-N64E9.1 with BC.