Open Access<p>Oxymatrine Inhibits Colorectal Cancer Metastasis via Attenuating PKM2-Mediated Aerobic Glycolysis</p>
Author(s) -
Xiaoping Li,
Jie Sun,
Qinghua Xu,
Wei Duan,
Lingyan Yang,
Xing Wu,
Guang Lu,
Li Zhang,
YunFeng Zheng
Publication year - 2020
Publication title -
cancer management and research
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s267686
Subject(s) - oxymatrine , pkm2 , cancer research , metastasis , pharmacology , medicine , in vivo , pyruvate kinase , colorectal cancer , glycolysis , cancer cell , cancer , chemistry , biology , metabolism , microbiology and biotechnology
Colorectal cancer (CRC), a type of highly occurred intestinal cancer at present, is prone to metastasis at the later stage of chemotherapy. Looking for the anti-metastatic agents from natural compounds attracted much concern. Here, it aims to demonstrate whether oxymatrine, an anti-cancer natural compound, has anti-metastatic activity and its potential significance in clinic.