Open AccessElevated Expression of CAV1 is Associated with Unfavorable Prognosis of Patients with Breast Cancer Who Undergo Surgery and Neoadjuvant Chemotherapy
Author(s) -
Jiahui Ye,
Jiajun Shi,
Xi Yin,
Hongyan Wu,
Xiaoyu Xu,
Yongzhong Yao,
Weijie Zhang
Publication year - 2020
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s264673
Subject(s) - breast cancer , medicine , oncology , chemotherapy , proportional hazards model , immunohistochemistry , cancer , multivariate analysis , biomarker , survival analysis , biology , biochemistry
Neoadjuvant chemotherapy (NACT), which is standard treatment for locally advanced breast cancer, improves the resectability of patients with early breast cancer and reduces the extent of breast and axillary surgery. Caveolin-1 (CAV1) is implicated in human cancers, although its utility for cancer prognosis is unknown. Here, we investigated the expression of CAV1 in breast cancer tissues to evaluate its prognostic significance on patients with breast cancer administered NACT.