Open Access<p>Hypoxic Non-Small-Cell Lung Cancer Cell-Secreted Exosomal microRNA-582-3p Drives Cancer Cell Malignant Phenotypes by Targeting Secreted Frizzled-Related Protein 1</p>
Author(s) -
Jian Wang,
Jia Zhao,
Jinsong Zhu,
Shengli Zhang
Publication year - 2020
Publication title -
cancer management and research
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s263768
Subject(s) - cancer research , microrna , cell , cell growth , microvesicles , lung cancer , exosome , cell migration , biology , downregulation and upregulation , western blot , metastasis , cancer cell , cancer , pathology , medicine , gene , biochemistry , genetics
Hypoxic environment and exosomes (exos)-mediated intercellular communication are crucial for cancer invasion and metastasis, but the mechanisms are not yet fully understood. In this study, we investigated the regulatory effect of hypoxic tumor cell-secreted exosomal miR-582-3p on non-small-cell lung cancer (NSCLC) cell malignant phenotypes.