Open Access<p>Evaluation of p16 in Epithelial Ovarian Cancer for a 10-Year Study in Northeast China: Significance of HPV in Correlation with PD-L1 Expression</p>
Author(s) -
Xinxin Yang,
Qian You,
GuoDong Yao,
Jingshu Geng,
Rong Ma,
Hongxue Meng
Publication year - 2020
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s262678
Subject(s) - hpv infection , immunohistochemistry , medicine , ovarian cancer , carcinogenesis , oncology , cancer research , concordance , etiology , biomarker , cancer , cervical cancer , biology , biochemistry
Human papillomavirus (HPV) is a high-risk etiological factor for cervical and ovarian carcinomas. p16 protein can be used as a surrogate biomarker for HPV infection in high-risk tumors. A strong correlation between HPV infection and programmed death ligand 1 (PD-L1) protein expression has consistently been reported.