Open Access<p><em>PINK1</em> Overexpression Promotes Cell Migration and Proliferation via Regulation of Autophagy and Predicts a Poor Prognosis in Lung Cancer Cases</p>
Author(s) -
Lü Xiao,
QuanXing Liu,
Jiao Zhang,
Dong Zhou,
Guixue Yang,
Manyuan Li,
Yuan Qiu,
Qian Chen,
Hong Zheng,
JiGang Dai
Publication year - 2020
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s262466
Subject(s) - pink1 , autophagy , mitophagy , cancer research , gene knockdown , pten , lung cancer , biology , a549 cell , apoptosis , western blot , gene silencing , medicine , pathology , pi3k/akt/mtor pathway , gene , genetics
Lung cancer remains the leading cause of cancer-related death worldwide. The human PINK1 gene (PTEN induced kinase 1, Park6), an important gene for Parkinson's disease, was found to be associated with tumor development although the molecular mechanisms underlying this relationship remain largely unknown.