Open Access<p>MiR-25-3p Serves as an Oncogenic MicroRNA by Downregulating the Expression of Merlin in Osteosarcoma</p>
Author(s) -
Hua-Chun Rao,
Zhaoke Wu,
Si-da Wei,
Yun Jiang,
Qingxin Guo,
Jiawen Wang,
Chang-Xian Chen,
Huiyong Yang
Publication year - 2020
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s262245
Subject(s) - merlin (protein) , moesin , cancer research , microrna , cell growth , osteosarcoma , biology , propidium iodide , ezrin , cell , cancer , suppressor , apoptosis , genetics , gene , programmed cell death , cytoskeleton
Moesin-ezrin-radixin-like protein (Merlin) has been identified as a tumor suppressor in several types of cancers. However, the biological function of Merlin in osteosarcoma remains unclear. MicroRNAs (miRNAs) can influence cancer progression by targeting oncogenes or anti-oncogenes. In this study, we sought to evaluate the regulation of Merlin expression by miR-25-3p and the role of the miR-25-3p/Merlin axis in osteosarcoma progression, with the aim of identifying a potential therapeutic target for osteosarcoma.