Open Access<p>Long Non-Coding RNA GAS5 Targeting microRNA-21 to Suppress the Invasion and Epithelial–Mesenchymal Transition of Uveal Melanoma</p>
Author(s) -
Qi Ying,
Qingqing Cui,
Wenjing Zhang,
Renjie Yao,
Dong Xu,
Fengyan Zhang
Publication year - 2020
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s260866
Subject(s) - gas5 , competing endogenous rna , gene knockdown , microrna , epithelial–mesenchymal transition , long non coding rna , cancer research , viability assay , downregulation and upregulation , biology , western blot , melanoma , mesenchymal stem cell , cell growth , metastasis , cell , chemistry , microbiology and biotechnology , cell culture , cancer , gene , genetics
Human uveal melanoma (UM) is a common ocular malignant tumor with a high risk of metastasis. Emerging evidence indicates that long non-coding RNAs (lncRNAs) are correlated with the development of UM. Here, we aimed to determine the biological significance of lncRNA growth arrest-specific transcript 5 (GAS5) in UM.