Open Access<p>NRP1 is a Prognostic Factor and Promotes the Growth and Migration of Cells in Intrahepatic Cholangiocarcinoma</p>
Author(s) -
Yingjie Wu,
Lihong He,
Zhongtian Bai,
Xun Li
Publication year - 2020
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s260091
Subject(s) - neuropilin 1 , gene knockdown , cancer research , oncogene , metastasis , cell growth , cell migration , cell , medicine , biology , cancer , cell culture , cell cycle , vascular endothelial growth factor , vegf receptors , genetics
Neuropilin-1 (NRP-1) participates in cancer cell proliferation and metastasis as a multifunctional co-receptor by interacting with multiple signaling pathways. However, few studies have addressed the precise function and prognosis analysis of NRP1 in intrahepatic cholangiocarcinoma (ICC). We aimed to study the correlations between NRP1 and clinicopathological characteristics and NRP1 effect on ICC cell line functions.