Open Access<p>Circular RNA ITCH Suppresses Cell Proliferation but Induces Apoptosis in Oral Squamous Cell Carcinoma by Regulating miR-421/PDCD4 Axis</p>
Author(s) -
Chunbo Hao,
Kaixin Wangzhou,
Zhengeng Liang,
Cheng Liu,
Linlin Wang,
Lei Gong,
Yi Tan,
Conghui Li,
Zhiying Lai,
Guangwei Hu
Publication year - 2020
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s258887
Subject(s) - apoptosis , cancer research , cell growth , circular rna , microrna , cell , cell culture , basal cell , flow cytometry , suppressor , mtt assay , biology , microbiology and biotechnology , chemistry , medicine , pathology , cancer , gene , genetics
Circular RNAs (circRNAs), a group of covalently closed non-coding RNAs, serve critical regulatory roles in many human cancers, including oral squamous cell carcinoma (OSCC). The purpose of this study was to investigate the functional role of circular RNA ITCH (circ-ITCH) in OSCC and the underlying mechanisms.