Open Access<p>Knockdown of circPRKCA Restrained Cell Growth, Migration, and Invasion of NSCLC Cells Both in vitro and in vivo via Regulating miR-330-5p/PDK1/AKT Pathway</p>
Author(s) -
Lanxiang Bai,
Xiaonu Peng,
Ramon C. Sun
Publication year - 2020
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s258370
Subject(s) - gene knockdown , protein kinase b , downregulation and upregulation , cancer research , cell growth , flow cytometry , pi3k/akt/mtor pathway , a549 cell , oncogene , viability assay , cell , chemistry , gene silencing , biology , microbiology and biotechnology , apoptosis , signal transduction , cell cycle , biochemistry , gene
Protein kinase Cα (PRKCA) is an oncogene in multiple cancers including non-small-cell lung cancer (NSCLC) and can be transcribed into a number of circular PRKCAs (circPRKCAs). Here, we aimed to elaborate the role and mechanism of circPRKCA_024 (circPRKCA) in malignant progression of NSCLC.