Open Access<p>Triptonide Modulates MAPK Signaling Pathways and Exerts Anticancer Effects via ER Stress-Mediated Apoptosis Induction in Human Osteosarcoma Cells</p>
Author(s) -
Zheng Lu,
Shiji Fang,
Hui Jing,
Vinothkumar Rajamanickam,
Minjiang Chen,
Qiaoyou Weng,
Xuanhao Wu,
Zhongwei Zhao,
Jiansong Ji
Publication year - 2020
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s258203
Subject(s) - mapk/erk pathway , apoptosis , p38 mitogen activated protein kinases , unfolded protein response , osteosarcoma , chemistry , cancer research , cytotoxic t cell , signal transduction , chop , microbiology and biotechnology , in vitro , biology , biochemistry
Osteosarcoma (OS) is the most common primary malignancy arise from bone and is one of the causes of cancer-related deaths. Triptonide (TN), a diterpenoid epoxide presented in Tripterygium wilfordii , is shown to possess a broad spectrum of biological properties.